The probiotic Lactobacillus reuteri and its metabolite reuterine perform a protective function against colorectal cancer. Thus concludes a US study published in Cancer Cell. (1)
The role of dysbiosis
Colorectal cancer it is among the most frequent cancers in the Italian population. It accounts for 11,6% of all cancers (excluding non-melanoma skin cancers) and is second only to that of the breast (14,6% of all cancers). (2)
The alteration of the microbiota intestinal (microbial dysbiosis) is now recognized as a hallmark of colorectal cancer and contributes to inflammation, tumor growth and response to therapy. It is less clear how these microbes operate with respect to the neoplasm.
The role of the probiotic
I ricercators Americans analyzed mouse models with induced colon cancer and fecal samples from people with this type of cancer. A reduced presence of Lactobacillus reuteri and its metabolite, reuterin, as well as other lactobacilli, such as Lactobacillus acidophilus.
The reduction of these microbes has also been ascertained in the tumor tissue, in comparison with the surrounding one.
Further experiments have shown that the Lactobacillus reuteri and reuterin break down the tumor mass, inducing the death of cancer cells and inhibiting the growth of new cells.
Il Lactobacillus reuteri is already being tested against various disorders and diseases, such as constipation, diarrhea, infantile colic, asthma, Helicobacter pylori. Its effectiveness against the second most common cancer opens great hopes, well pinned.
Our results indicate that a healthy microbiome and, in particular, Lactobacillus reuteri, is protective against CRC'(colorectal cancer, ed), the study authors conclude.
Cover image by Ana Aleksic (2021). Potential Benefits of the Lactobacillus reuteri Probiotic. Selfhacked.
(1) Hannah N. Bell, Ryan J. Rebernick, Joshua Goyert, Steven P. Gygi, Joseph D. Mancias, Yatrik M. Shah et al. (2021) Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance. Cancer Cell. 23.12.2021 DOI: https://doi.org/10.1016/j.ccell.2021.12.001
Professional journalist since January 1995, he has worked for newspapers (Il Messaggero, Paese Sera, La Stampa) and periodicals (NumeroUno, Il Salvagente). She is the author of journalistic surveys on food, she has published the book "Reading labels to know what we eat".